Inês Santos Silva

Guest Profile

Women's Health, Ovarian Aging & When Hormones Get Mistaken for Depression

Inês Santos Silva

Entrepreneur & Healthcare Builder · Co-Founder & COO of TejoMed, Lisbon
Part of the team behind AthenaDAO · Alcohol-free since birth

Women's Health Hormones Longevity Preventive Medicine Ovarian Aging Social Connection

About Inês

Inês Santos Silva is a Portuguese entrepreneur working at the intersection of women's health, preventive medicine, and longevity. She is Co-Founder and COO of TejoMed, a membership-based family medicine clinic in Lisbon built around personalized, preventive care — and part of the team behind AthenaDAO, which funds research into women's health.

Her work grew out of personal experience: after struggling with health issues that fell between medical specialties in her mid-twenties, Inês began researching the gaps in women's healthcare herself. She found a field shaped almost entirely by male biology — from clinical trials to diagnostic thresholds — and decided to help change it.

Today she is focused on building better science, better data, and more personalized care for women across every stage of life — from hormonal shifts in their twenties to the long-term consequences of ovarian aging and menopause.

PeakSpan Episode 04 — Inês Santos Silva
EPISODE 04 Listen to the full episode

What You'll Learn

The women's health blind spot. Why medicine still treats women as a variation of the male body — and what that costs in diagnosis, treatment, and longevity outcomes.
The ovarian aging question. What menopause, fertility, and women's long-term health have in common — and why the science is still catching up to the biology.
The hormonal misdiagnosis. Why symptoms like low energy, depression, and loss of drive are routinely dismissed as mental health issues when the full hormonal picture hasn't been examined.
The longevity obsession trap. How health optimization can become another source of pressure — and why the most effective protocol is the one that actually fits your life.
The social connection prescription. Why belonging, purpose, and time with other people may be among the most underestimated drivers of resilience, peak performance, and healthspan.

Key Takeaways

1
Women's bodies are not smaller male bodies — but medicine treated them that way for 200 years. Most clinical research used male subjects as the default. The downstream effects on diagnosis, dosing, and treatment for women are still being mapped — and still causing real harm today.
2
Ovarian aging may be the central lever for female longevity. The ovaries are the fastest-aging organ in the female body. They regulate not just fertility but hormones that govern cardiovascular health, bone density, cognition, and metabolic function. Delaying menopause could reframe the entire female healthspan conversation.
3
Hormonal imbalances are routinely mislabelled as anxiety or depression. Women come to TejoMed saying they don't feel like themselves — lost drive, low energy, mood shifts. The medical default is psychiatric labels. The real driver is often hormonal. Inês believes continuous hormone tracking (like CGMs for glucose) is coming — and it can't come fast enough.
4
Endometriosis affects 1 in 10 women and takes 7–10 years to diagnose. Once diagnosed, the standard response is suppression — not solution. PCOS follows the same pattern. These are not niche issues: they affect hundreds of millions of women globally, yet research funding remains a fraction of what comparable conditions attract.
5
Women live longer but spend 25% more time in poor health. Around nine additional years in poor health — a gap that is almost entirely preventable with better science, earlier intervention, and care that actually reflects female biology. Longevity for women isn't just about lifespan. It's about healthspan.
6
The best protocol is the one you actually do. Inês never obsesses over perfection. If she eats something she shouldn't, she moves on — just doesn't do it two days in a row. Her insight: the transition from protocol to habit is the real goal. A checklist you follow is useful; a lifestyle you live is transformational.
7
Social connection is the most underweighted longevity lever. Inês closed the episode by naming belonging and purpose — not supplements, not biomarkers — as her top priority for the future of longevity. We are in a crisis of belonging, she says, and we need to be far more intentional about reversing it.
"Women are 51.5% of the world's population. It's funny — people call this a niche. If it's a niche, it's the biggest niche in the world."
"A lot of the times, women are treated for depression. What they actually have is hormonal imbalances — and we completely miss it."
"Being at my peak is when I feel that energy in me — mental and physical at the same time. There are seasons where that's easier to find. But that's what I'm looking for."

Episode Chapters

01:01From Business to Women's Health Research
  • Inês has an entrepreneurship and innovation background, not a science background, and came to longevity through her own unresolved health issues at age 25–26 that fell “in between specialties” of a hyper-specialized healthcare system.
  • In 2022, near the end of the pandemic, she sold her shares in her consultancy firm and got involved in “Decentralized Science” (DeSci), a movement to fund scientific research directly.
  • That led her to found AthenaDAO, an organization focused on funding women's health research, after meeting a group of women in Berlin.
  • In 2024 she co-founded TejoMed, a membership-based family medicine clinic in Lisbon, to give patients the integrated, preventive care she couldn't find for herself.
05:26Why She Never Touched Alcohol
  • At age 8, Inês read in a magazine (Super Interesting) that alcohol “kills your neurons” and decided then never to drink — she is 36 and has never had alcohol.
  • She also watched alcohol affect the children of her parents' friends, reinforcing the decision.
  • Her grandmother's Alzheimer's diagnosis, witnessed as a young child, was a second formative influence tying brain health to lifelong habits.
  • Childhood team sports (football) gave her an early, intuitive sense that exercise affects mental as well as physical health — long before she knew any of the science.
10:22Her Daily Longevity Protocol
  • Exercises at least 30 minutes daily (strength training plus cardio/walking), always before lunch — mornings don't work for her, evenings leave her too mentally tired.
  • Combines exercise with time in nature specifically, not city parks, because she says “the waves in our brain” change differently in a forest setting.
  • Sleep: consistent bed/wake times, immediate sunlight after waking (via a daily dog walk), and eating dinner early — around 6–6:30pm before a 10–10:30pm bedtime — which she tracks via Whoop as her single biggest lever for sleep quality.
  • Nutrition: low-carb, low-sugar diet; eats meat despite a vegetarian past because she has low iron.
  • Supplements: iron, vitamin D, omega-3, K2, and magnesium before bed. Meditates 10 minutes daily, which she says immediately raises her HRV that same night.
17:38Testing, Iterating, and Not Becoming Obsessed
  • She tried near-daily sauna use for a period and tracked biomarkers but saw no measurable impact on sleep or HRV — unlike meditation or early eating, which show immediate, visible effects.
  • Her exercise timing changed from evenings (6pm) to before lunch (12pm) because the mental benefits were the same but the motivation required to start was far lower at midday.
  • She warns that longevity culture on platforms like X can look like “a full-time job,” and says she deliberately limits herself to testing only the levers she believes matter most rather than trying everything.
  • Her rule for staying balanced: an occasional slip is fine as long as it doesn't happen two days in a row — the protocol became a habit, not a checklist.
26:29The Women's Health Research Gap (AthenaDAO)
  • Women are 51.5% of the world's population — in her words, “if it's a niche, it's the biggest niche in the world.”
  • Modern medicine's baseline assumptions were built on studying male bodies first; only recently has research shown women differ from men down to the cellular level. Women live longer than men but spend roughly 25% more of that time in bad health.
  • Endometriosis affects 1 in 10 women and takes 7–10 years on average to diagnose; treatment often defaults to surgery or continuous birth control rather than addressing the root cause.
  • Menopause is still largely unexplained biologically — humans, giraffes, and whales are among the only species known to experience it — yet it sharply increases cardiovascular risk and worsens bone and mental health.
  • She names three systemic gaps: a science gap (too little research), a data gap (not enough data to make AI tools useful for women's health), and a care gap (doctors undertrained on menopause and female-specific heart attack symptoms).
35:04Hormones and Mental Health: The Depression Misdiagnosis
  • The most common complaint she hears from women is “I don't feel like myself” — lost drive, lost energy, low mood — which she attributes largely to hormonal shifts, not primarily physical symptoms.
  • She predicts continuous hormone monitoring (similar to today's continuous glucose monitors) is coming soon, letting people track hormonal cycles the way they already track blood sugar.
  • Thyroid hormones, not just estrogen and progesterone, have a major and underrated impact on mental health.
  • She believes many women treated for depression actually have underlying hormonal imbalances that could be addressed through hormone replacement therapy combined with exercise and nutrition changes.
39:19Building TejoMed: Preventive, Personalized Family Medicine
  • TejoMed pairs each patient with one dedicated doctor who knows their full history, rather than a rotation of specialists who each look at the patient from a narrow lens.
  • The model combines that continuity of care with “Medicine 3.0” principles — more preventive, proactive, and personalized than typical reactive healthcare.
  • Founded with co-founder Tyler in 2024; based in Lisbon, with plans to expand to other locations.
  • Patients most often come to TejoMed for access to a doctor who knows them well and for proactive, preventive checkups rather than one-off problem-solving.
45:22The Future of Longevity: Social Connection and Research Priorities
  • Asked where longevity research should focus next, she names social connection first — describing a “crisis of belonging” driven by screen time replacing the random, in-person connection people used to have by default.
  • She calls connection “a muscle that needs to be trained” and argues people now need to be deliberate about it since it no longer happens automatically.
  • On research funding, she wants more money directed at menopause, ovarian aging, endometriosis, and PCOS — and at diseases that disproportionately affect women, citing that two-thirds of Alzheimer's patients are women and that cardiovascular disease is the number-one cause of death in women.
  • Her framing: research funding leads to more companies, which leads to better treatments — without the research, founders in women's health are stuck managing symptoms rather than solving root causes.
49:21What “Peak” Feels Like
  • She describes her peak state as a flow state — most vividly recalled from playing football as a child, where “there was nothing else” and time stopped being a construct.
  • She finds it harder to reach that same flow state through meditation than she did through sport.
  • Longer-term, she describes “peak” as a mental-and-physical energy that builds up from consistent habits (exercise, nutrition) rather than a single peak moment.

Disclaimer

Medical disclaimer. The information in this episode is for educational purposes only and is not medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making decisions about your health.

At a Glance

37
Years old, never had alcohol
30 min
Daily exercise, non-negotiable
6–6:30pm
Nightly dinner cutoff, tracked via Whoop
Mid-20s
When her own health gaps sparked TejoMed

TejoMed is a membership-based preventive medicine clinic in Lisbon. AthenaDAO funds research into ovarian aging, menopause, and women's health — areas chronically starved of scientific investment.

Inês's Personal Protocol

🏃
Daily Exercise — 30 min minimum
Strength training + cardio; midday timing (pre-lunch) works best for her — acts as a full mental reset for the afternoon
🌲
Exercise in Nature
Combining movement with outdoor environments — brain wave changes, air quality, mental restoration. A non-negotiable upgrade
🐕
Dog Walk at Wake-Up
Immediate morning sunlight + movement — "having a dog makes it non-optional, which I love"
🍽️
Early Dinner (6–6:30pm)
Tracked with Whoop — eating early is her single biggest sleep quality lever. Measurable impact on HRV every night
🧘
10-Min Daily Meditation
Immediately measurable — on nights she meditates, HRV visibly improves. Simple, consistent, non-negotiable
💊
Targeted Supplements Only
Iron, Vitamin D, K2, Omega-3, Magnesium — all based on tested deficiencies, not trends. Nothing extra

Research & Concepts

Ovarian Aging & Menopause Timing
Ovaries are the fastest-aging organ in the female body. Earlier menopause correlates with shorter healthspan. AthenaDAO is funding research to understand and delay this process.
The Gender Data Gap in Medicine
200 years of research built on male subjects. Female physiology differs at the cellular level — yet drug dosages, diagnostic criteria, and protocols are still calibrated on men.
Heart Attack Symptoms Differ in Women
Cardiovascular disease is the #1 cause of death in women globally. The symptoms present differently from men — and most medical training still doesn't reflect this.
Alzheimer's: Two-Thirds Female
Women make up roughly two-thirds of Alzheimer's patients. The biological reasons remain poorly understood — and significantly underfunded given the scale of impact.